This can happen if there is destruction of the adrenal cortex (primary insufficiency) or if factors outside of the adrenal glands stimulate them to produce less cortisol (secondary insufficiency). Īdrenal insufficiency is a well-documented condition in which the adrenals cannot keep up with the stress response of the body. The adrenals are also responsible for producing aldosterone and sex hormones. These chemicals increase heart rate and blood pressure, diverting blood to the brain, heart, and skeletal muscle. When the sympathetic (fight or flight) nervous system is activated, the adrenals respond by releasing epinephrine, norepinephrine, and cortisol. The adrenal glands are located at the center of the body’s stress response system. A wide array of hormones and neurotransmitters exist to maintain homeostasis in response to physical and psychogenic stressors. The human body is well equipped to handle stress. VA Software Documentation Library (VDL).Clinical Trainees (Academic Affiliations).War Related Illness & Injury Study Center.
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